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The genomic sequence of 2019-nCoV indicates that the virus clusters with betacoronaviruses of lineage b.
2019-nCoV S-protein sequence has a specific furin-like cleavage site absent in lineage b CoV including SARS-CoV sequences.
The furin-like cleavage site in the S-protein of 2019-nCoV may have implications for the viral life cycle and pathogenicity.
Campaigns to develop anti-2019-nCoV therapeutics should include the evaluation of furin inhibitors.
Abstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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马云现象的经济学分析：互联网经济的八个关键命题
胡晓鹏 / 上海社会科学院出版社 / 2016-11-1 / CNY 68.00
互联网经济的产生、发展与扩张，在冲击传统经济理论观点的同时，也彰显了自身理论体系的独特内核，并与那种立足于工业经济时代的经典理论发生显著分野。今天看来，“马云”们的成功是中国经济长期“重制造、轻服务，重产能、轻消费，重国有、轻民营”发展逻辑的结果。但互联网经济的发展却不应仅仅止步于商业技巧的翻新，还需要在理论上进行一番审慎的思考。对此，我们不禁要问：互联网经济驱动交易发生的机理是什么？用户基数和诚......一起来看看 《马云现象的经济学分析：互联网经济的八个关键命题》 这本书的介绍吧!
