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The genomic sequence of 2019-nCoV indicates that the virus clusters with betacoronaviruses of lineage b.
2019-nCoV S-protein sequence has a specific furin-like cleavage site absent in lineage b CoV including SARS-CoV sequences.
The furin-like cleavage site in the S-protein of 2019-nCoV may have implications for the viral life cycle and pathogenicity.
Campaigns to develop anti-2019-nCoV therapeutics should include the evaluation of furin inhibitors.
Abstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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网络江湖三十六计
程苓峰，王晶 / 经济日报出版社 / 2009-6 / 40.00元
《网络江湖三十六计》内容简介：貌合神离：卖个破绽给对手，让他尝到甜头，自认为可安枕无忧，往往就松懈大意。于是，自己蓄力并反击的机会就来了。诱敌就是“貌合”，暗地发力就是“神离”。一起来看看 《网络江湖三十六计》 这本书的介绍吧!
