Highlights
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The genomic sequence of 2019-nCoV indicates that the virus clusters with betacoronaviruses of lineage b.
2019-nCoV S-protein sequence has a specific furin-like cleavage site absent in lineage b CoV including SARS-CoV sequences.
The furin-like cleavage site in the S-protein of 2019-nCoV may have implications for the viral life cycle and pathogenicity.
Campaigns to develop anti-2019-nCoV therapeutics should include the evaluation of furin inhibitors.
Abstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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Python编程实践
Jennifer Campbell、Paul Gries、Jason Montojo、Greg Wilson / 唐学韬 / 机械工业出版社华章公司 / 2011-12-31 / 49.00元
Python是当今世界流行的编程语言之一。本书共15章，通过一些短小精悍的交互式Python脚本帮助学生进行练习，并在这个过程中掌握诸如数据结构、排序和搜索算法、面向对象编程、数据库访问、图形用户界面等基本概念以及良好的程序设计风格。本书既是一本注重科学的计算机科学专业教材，也是一本目标明确的Python参考书。 本书语言风格言简意赅，图表丰富，简单实用，是一本优秀的Python入门级读物，......一起来看看 《Python编程实践》 这本书的介绍吧!
