Highlights
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The genomic sequence of 2019-nCoV indicates that the virus clusters with betacoronaviruses of lineage b.
2019-nCoV S-protein sequence has a specific furin-like cleavage site absent in lineage b CoV including SARS-CoV sequences.
The furin-like cleavage site in the S-protein of 2019-nCoV may have implications for the viral life cycle and pathogenicity.
Campaigns to develop anti-2019-nCoV therapeutics should include the evaluation of furin inhibitors.
Abstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
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Java 8实战
厄马(Raoul-Gabriel Urma)、弗斯科(Mario Fusco)、米克罗夫特(Alan Mycroft) / 陆明刚、劳佳 / 人民邮电出版社 / 2016-4-1 / CNY 79.00
本书全面介绍了Java 8 这个里程碑版本的新特性，包括Lambdas、流和函数式编程。有了函数式的编程特性，可以让代码更简洁，同时也能自动化地利用多核硬件。全书分四个部分：基础知识、函数式数据处理、高效Java 8 编程和超越Java 8，清晰明了地向读者展现了一幅Java 与时俱进的现代化画卷。一起来看看 《Java 8实战》 这本书的介绍吧!
