Highlights
- •
- •
- •
- •
The genomic sequence of 2019-nCoV indicates that the virus clusters with betacoronaviruses of lineage b.
2019-nCoV S-protein sequence has a specific furin-like cleavage site absent in lineage b CoV including SARS-CoV sequences.
The furin-like cleavage site in the S-protein of 2019-nCoV may have implications for the viral life cycle and pathogenicity.
Campaigns to develop anti-2019-nCoV therapeutics should include the evaluation of furin inhibitors.
Abstract
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.
以上所述就是小编给大家介绍的《2019-nCoV may contain a gain-of-function for efficient spreading》，希望对大家有所帮助，如果大家有任何疑问请给我留言，小编会及时回复大家的。在此也非常感谢大家对 码农网 的支持！
猜你喜欢:
本站部分资源来源于网络，本站转载出于传递更多信息之目的，版权归原作者或者来源机构所有，如转载稿涉及版权问题，请联系我们。
Realm of Racket
Matthias Felleisen、Conrad Barski M.D.、David Van Horn、Eight Students Northeastern University of / No Starch Press / 2013-6-25 / USD 39.95
Racket is the noble descendant of Lisp, a programming language renowned for its elegance and power. But while Racket retains the functional goodness of Lisp that makes programming purists drool, it wa......一起来看看 《Realm of Racket》 这本书的介绍吧!
